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3D biology
with a 2D workflow.

MOSgenTM is the first benchtop platform built for high-throughput 3D biology. It generates uniform, permeable cell-matrix microdroplets at industrial scale, ready for any standard assay.

Request a demo or Early Access
Or grab the flyer — case studies, specs → PDF
Scale.Standardized.Simple.
Throughput / lane
70kMOS
≈ 1,750 wells at 40 MOS/well, in 15 minutes. Up to 4 lanes in parallel.
Uniformity
< 3% CV diameter
Image-driven PID size control. Uniform from droplet 1 to 70,000.
MOS size · volume
240µm · 7 nL
Cell-matrix integrated microdroplets. Permeable to stains, antibodies, T-cells.
FLEXIBLE
Drop-inworkflow
Flexibility around your existing reagents, labware, and instruments.

3D biology is essential.
Scaling has been the bottleneck — until now.

Nearly 90% of drugs entering clinical trials fail, driven in part by preclinical models that poorly predict human biology. MOSgen is a bench-ready microfluidic device that produces MOS® — uniform, permeable 3D cell-matrix microdroplets — at industrial scale. Pipettable like a liquid, drop-in compatible with the instruments your team already owns.

MOSgen generates up to 280,000 MOS in 15 minutes across four parallel lanes using single-use consumables with zero dead volume. Any cell type. Any standard plate. Any downstream assay.

Using image-driven PID control holds droplet diameter to under 3% CV with near-zero cell loss — uniform replicates, run after run.

Now accepting applications for limited paid evaluation units for placement at HTS cores, pharma R&D groups, and translational research programs across the US.

MOSgen — by the numbers

MOS produced per lane70,000
Parallel lanes per run4
Run time< 15 min
MOS starting cell density1 – 400
MOS diameter uniformity< 3% CV
Confirmed matrix compatibilityPEG, Matrigel, Collagen
Downtime between back-to-back runs0 min
Sample input compatibilityPatient, iPSC, organoid, spheroid, clonal line, primary tissue, PDXO

Meet MOS®.

Each MOS is a 7 nL, ~240 µm cell-containing matrix microdroplet — permeable to stains, antibodies, and T-cells. Pipettable like a liquid, biologically complete inside.

Uniform MOS microdroplets at ~240 µm diameter
Brightfield · uniform MOS · PRIMARY PATIENT DAY 3

See native immune cells find and kill tumor cells.
In real time.

Watch a killing event at single-MOS resolution, or zoom out to whole-well biology across drug modalities.

Primary NSCLC patient-derived MOS
CD45+ immune cells
Epithelial cell death
Wide field of MOS context viewWide field of MOS context
Wide field of MOS contextWide field of MOS context view

An endogenous CD45+ immune cell engages an epithelial cell inside the MOS — and the death signal blooms as it dies.

  • ›Epithelial cells stay contained in the MOS. Smaller immune cells move freely — entering and exiting on their own.
  • ›A native immune cell interacts with an epithelial cell — triggering it to die. The red signal blooms in real time, specific to epithelial death.
Live killing across two immunotherapy modalities.
whole-well
Epithelia
Epithelial death
T-Cell Engager
Endogenous T-cells kill in response to a bispecific T-cell engager.
The patient's own immune cells, activated against their own tumor — live at well scale.
whole-well
Epithelia
Epithelial death
Cell therapy
Autologous TILs engage and kill NSCLC tumor cells.
Functional readout for adoptive cell therapy potency — live at well scale.
Want the full data? Download the MOSgen flyer

What 280,000 MOS in 15 minutes looks like.

Four lanes, one 15-minute run. Image-driven PID holds < 3% diameter CV throughout.
Live run · 4 lanes
Ø ~240 µm · CV < 3%
15-minute run
70,000 MOS / lane

Built for the work your team already does — at the scale you've never had.

High-throughput screening.
Primary and secondary screens. Full multi-compound  IC50 curves from a single lane. 96, 384, 1536 plate formats.
ADCs, TCEs, TILs.
Co-cultures with exogenous or endogenous T-cells. Purpose-built for IO programs running primary patient samples.
Single-MOS resolution.
High replicate power per well. Live imaging, flow, viability — no new instrumentation required.
Patient-derived, in days.
Predict ex vivo responses that map to patient outcomes. Workflows in days, not months.

Tell us what brings you here.

Pick the reason that fits and we'll route your message to the right person.

HQResearch Triangle, NC · United States
Demo requests[email protected]
General[email protected]
Response timeWithin 24 hours
StatusAccepting Early Access applications now
Step 1 · Reason for contact
Request a demo or Early AccessInvestment & partnershipsGeneral informationGet the flyer
Step 2 · Your details
We respond within 24 hours of receiving your inquiry.
MOSgen is currently Research Use Only.
Thank you! Your submission has been received!
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Thanks — we've got it.

We'll respond within 24 hours to schedule a conversation. In the meantime, feel free to bookmark uniformbio.com — the full site goes live with our product launch.

Download MOSgen flyer (PDF)
Inquiry received · routed to the right team